On screen
Cast
86 credited performers
Bill Nye
Self - Host
Derek Muller
Self - Correspondent
Karlie Kloss
Self - Correspondent
Prashanth Venkataramanujam
Cookies & Cream (voice)
Nazeem Hussain
Self - Correspondent
Zach Braff
Self
Rachel Bloom
Martian
Cece Pleasants Adams
HPV
Sanden Totten
Self - Voice of Refrigerator (voice)
Margaret Cho
Pistachio (voice)
Cara Santa Maria
Self - Correspondent
Joanna Hausmann
Self - Correspondent
Emily Calandrelli
Self - Correspondent
Desiigner
Self
Tracy Mann
Self - Panelist
Sara Benincasa
Self - Panelist
Jennifer Widerstrom
Self - Panelist
Martin Starr
Doug the Caveman
Lauren Ash
Kale
Jeff Dye
Eggplant
Andi Osho
Bread
Heather McDonald
Beef
Aubrey Anderson-Emmons
The Director
Robb Fraley
Self - Panelist
Fred Gould
Self - Panelist
Julie Kennye
Self - Panelist
Katrina Karkazis
Self - Panelist
Jeffrey McCune Jr.
Self - Panelist
Solomon Georgio
Self - Panelist
Todd Barry
Vanilla (voice)
Sandra Bernhard
Mint Choc Chip (voice)
Matt Lucas
Salted Caramel (voice)
Mario Cantone
Strawberry (voice)
Cameron Esposito
Chocolate (voice)
Nicole Go
DJ Seahorse
Ryan Calo
Self - Panelist
Xeji Jardin
Self - Panelist
Subbarao Kambhampati
Self - Panelist
Neil deGrasse Tyson
Self - Voice of Coffee Maker (voice)
Salim Shaikh
Self
Margaret Mitchell
Self
Prof. Mark Jacobson
Self - Panelist
Richard Martin
Self - Panelist
Taryn O'Neill
Self - Panelist
Steve Aoki
Self
Chris Beedie
Self - Panelist
Donald Schultz
Self - Panelist
Alton Brown
Self
Hunter Pence
Self
Randy Couture
Tardigrade
Marcus Lindsay
Tardigrade Victim
Andy Rossi
Tardigrade Victim
Moogega Cooper
Self - Panelist
Hakeem Muata Oluseyi
Self - Panelist
Wil Wheaton
Self - Panelist
Lanre Falusi
Self - Panelist
Kristen Omeara
Self - Panelist
Jennifer Reich
Self - Panelist
Diedrich Bader
Smallpox
Jim O'Heir
Rabies
John O'Hurley
Influenza
George Wendt
Polio
Hilarie Cash
Self - Panelist
Shawn Green
Self - Panelist
Jonna Mae
Self - Panelist
Gustavo Sorola
Rooster Teeth
Geoff Ramsey
Rooster Teeth
Tim Gunn
Self
Camille Hammond
Self - Panelist
Leslie Hinkson
Self - Panelist
Paul Knoepfler
Self - Panelist
Nerys Benfield
Self - Panelist
Travis Rieder
Self - Panelist
Rachel Snow
Self - Panelist
Kevin Smith
Self - Panelist
Steve-O
Self
Ali Wong
Self
Drew Carey
Self
Damian Kulash
Self
Tim Nordwind
Self
Dan Konopka
Self
Andy Ross
Self
Scott Kelly
Self
Maria Bamford
Self
Paul F. Tompkins
Self
Joel McHale
Self