On screen
Cast
253 credited performers
David Letterman
Self - Host
Calvert DeForest
Self (uncredited)
Jerry Seinfeld
Self - Guest
Lou Reed
Self - Musical Guest
Bruce Willis
Self - Guest
David Sanborn
Self - Musical Guest
Bruno Kirby
Self - Guest
John Waters
Self - Guest
Catherine O'Hara
Self - Guest
Jay Leno
Self - Guest
Dolly Parton
Self - Guest
Eddie Murphy
Self - Guest
Marv Albert
Self - Guest
Darlene Love
Self - Musical Guest
Joel Hodgson
Self
Terry Gilliam
Self
Timothy Busfield
Self
Shelley Winters
Self - Guest
Penelope Ann Miller
Self
John Candy
Self - Guest
Dana Delany
Self - Guest
Garry Kasparov
Self - Guest
Richard Lewis
Self - Guest
Don Rickles
Self - Guest
Chris Elliott
The Regulator Guy
Iggy Pop
Self - Musical Guest
Andie MacDowell
Self - Guest
Bill Cosby
Self
Lisa Bonet
Self - Guest
Norm Macdonald
Self
Joe Regalbuto
Self
Bonnie Hunt
Self
Helen Hunt
Self
Julia Roberts
Self
Manute Bol
Self
Jessica Savitch
Self
Paula Poundstone
Self - Guest
Jack Palance
Self - Guest
Gilda Radner
Self
Shawn Colvin
Self - Musical Guest
John Turturro
Self - Guest
Phil Hartman
Self - Guest
Elle Macpherson
Self - Guest
Walter Kowalski
Self - Guest (as Walter "Killer" Kowalski)
Michael Caine
Self - Guest
Kurt Russell
Self - Guest
Demi Moore
Self - Guest
Paul Reiser
Self - Guest
Jane Pauley
Self - Guest
Adam West
Self - Guest
Bill Murray
Self - Guest
Wayne Newton
Self - Guest
Bette Davis
Self - Guest
Charles Grodin
Self - Guest
Crispin Glover
Self - Guest
Regis Philbin
Self - Guest
Biff Henderson
Self
Sean Young
Self - Guest
Jeff Altman
Self - Guest
William Shatner
Self - Guest
Carol Kane
Self
Jonathan Winters
Self
Ann Wedgeworth
Self
Tim Thomerson
Self
Rip Taylor
Self
Jim Belushi
Self
Rob Reiner
Self
Robert Vaughn
Self
O. J. Simpson
Self
Tom Bodett
Self
Dick Clark
Self
Thomas F. Wilson
Self
Bob Newhart
Self - Guest
Robert Downey Jr.
Self - Guest
Bebe Neuwirth
Self
John Larroquette
Self
Linda Hamilton
Self
Ed O'Neill
Self
Kathryn Harrold
Self
Patrick Dempsey
Self
Jason Priestley
Self
Bill Nye
Self
Janine Turner
Self - Guest
Marisa Tomei
Self
Jason Alexander
Self
Bob Hope
Self
Chris Mulkey
Self
Elizabeth Ashley
Self
Richard Kiel
Self
Oprah Winfrey
Self
Laraine Newman
Self - Guest
Eric Roberts
Self
Steve Landesberg
Self - Guest
Luke Perry
Self
Lysette Anthony
Self
Adam Arkin
Self
John Kruk
Self
Tony Danza
Self
Ben Stiller
Self
Michael Jordan
Self
Tom Kenny
Self
Sting
Self - Guest
Sandra Bernhard
Self
Bill Maher
Self
Tim Conway
Self
Bobby Knight
Character not listed
Kris Kristofferson
Character not listed
Warren Zevon
Self
Gretchen Polhemus Jensen
Self
Marky Ramone
Self - Guest
Bill Bradley
Self
Ernie Banks
Self
Johnny Cash
Self - Musical Guest
John Malkovich
Self - Guest
Penn Jillette
Self - Guest
Teller
Self - Guest
Aaron Neville
Self - Musical Guest
Digable Planets
Self - Musical Guest
Rae Dawn Chong
Self - Guest
Tito Puente
Self -Musical Guest
John Wesley Shipp
Self - Guest
Joe Pesci
Self - Guest
Kathleen Turner
Self - Guest
Elayne Boosler
Self - Guest
Charles Kuralt
Self - Guest
Robert Pastorelli
Self - Guest
Paul Sorvino
Self - Guest
Michael J. Fox
Self - Guest
Dean Stockwell
Self - Guest
Tony Bennett
Self - Guest
John Chancellor
Self - Guest
Kathy Shower
Self - Guest
Fred Dryer
Self - Guest
Chuck Norris
Self - Guest
Jimmie Walker
Self
Sharon Stone
Self - Guest
Jake Johannsen
Self - Comedian
David Cronenberg
Self - Guest
Dee Snider
Self - Guest
Dennis Miller
Self - Guest
Louie Anderson
Self - Comedian
Rodney Dangerfield
Self - Guest
Rosanne Cash
Self - Musical Guest
Sam Kinison
Self - Guest
Lesley-Anne Down
Self - Guest
Charlie Hill
Self - Guest
Letitia Baldrige
Self - Guest
Tama Janowitz
Self - Guest
Robben Ford
Self - Musical Guest
Elizabeth Perkins
Self - Guest
Eric Idle
Self - Guest
Harvey Pekar
Self - Guest
Kirstie Alley
Self - Guest
Christopher Walken
Self - Guest
Spin Doctors
Self - Musical Guest
Richard Petty
Self - Guest
Sam Donaldson
Self - Guest
Jeff Healey
Self - Musical Guest
Lesley Ann Warren
Self - Guest
Kreskin
Self - Guest
Milla Jovovich
Self - Guest
Pauly Shore
Self - Guest
Don Herbert
Self - Guest (as Mr. Wizard)
Pat Paulsen
Self - Guest
Steve Tesich
Self - Guest
Dr. Norman Hoffman
Self
Hank Aaron
Self - Guest
Al Albert
Self - Guest
Irving Caesar
Self - Guest
Joe Flaherty
Self - Guest
Rita Stipo
Self - Guest
Francis Ford Coppola
Self - Guest
Henry Morgan
Self - Guest
Dr. Walter Fairservis
Self - Guest
Alec Baldwin
Self - Guest
Ruth Westheimer
Self - Guest
Andy Kaufman
Self - Guest
Carole King
Self - Guest
Charles O. Finley
Self - Guest
Jerry Lewis
Self - Guest
Gloria Parker
Self - Guest
Costas Mandylor
Self - Guest
Rickey Henderson
Self
Jack Hanna
Self - Guest
Suzanne Vega
Self - Musical Guest
Dick Cavett
Self - Guest
Rubén Blades
Self - Musical Guest
Cindy Crawford
Self - Guest
Al Green
Self - Musical Guest
Amy Wallace
Self - Guest
Joe Jackson
Self - Musical Guest
Basia Trzetrzelewska
Self - Musical Guest (as Basia)
Susanna Hoffs
Self - Musical Guest
Billy Dee Williams
Self - Guest
Robbie Coltrane
Self - Guest
Ringo Starr
Self - Guest
Rick Ducommun
Self - Guest
Joey Ramone
Self - Guest
Jacques Pépin
Self - Guest
Johnny Ramone
Self - Guest
Clint Howard
Self - Guest
Ally Sheedy
Self - Guest
Tom Brokaw
Self - Guest
Toukie Smith
Self - Guest
Jackie Mason
Self - Guest
Tim Robbins
Self - Guest
Johnny Dark
Self - Guest
Maria Shriver
Self - Guest
Mavis Staples
Self - Musical Guest
Dwight Yoakam
Self - Guest
Morley Safer
Self - Guest
Divine
Self - Guest
Robin Williams
Self - Guest
Norman Lear
Self - Guest
Paulina Porizkova
Self - Guest
Bonnie Raitt
Self - Musical Guest
Tahnee Welch
Self - Guest
Tom Snyder
Self - Guest
Mary Gross
Self - Guest
Joe Walsh
Self - Musical Guest
Joan Cusack
Self - Guest
Robert Palmer
Self - Musical Guest
Larry King
Self - Guest
Bill Bradley
Self - Guest
Billy Carter
Self - Guest
Errol Morris
Self - Guest
Tracey Ullman
Self - Guest
Linda Ronstadt
Self - Musical Guest
Howard Stern
Self - Guest
Leon Russell
Self - Musical Guest
Sarah Michelle Gellar
Suzy Walker
William Perry
Self - Guest
Emmanuel Lewis
Self - Guest
Debbie Reynolds
Self - Guest
Tower of Power
Self - Musical Guest
Tony Randall
Self - Guest
Harry Connick Jr.
Self - Musical Guest
Ruth Brown
Self - Musical Guest
Wayne Gretzky
Self - Guest
Gary Moore
Self - Musical Guest
Danny Aiello
Self - Guest
Amy Madigan
Self - Guest
David Lowery
Self - Musical Guest
Johnny Hickman
Self - Musical Guest
Bob Rupe
Self - Musical Guest
Bette Sussman
Self
Debra Ponzek
Self - Guest
Jennifer Finch
Self - Musical Guest
Suzi Gardner
Self - Musical Guest
Demetra Plakas
Self - Musical Guest
Donita Sparks
Self - Musical Guest
Illeana Douglas
Self - Guest
Billy Bragg
Self - Musical Guest